Pharmaceutical Chemistry

During the PhD. study, the student acquires knowledge in the field of Pharmaceutical Chemistry in this study program. The main goal is focused on the design, synthesis, analysis, and evaluation of biologically active compounds. In the study, the students learn to form a scientific problem independently, to form a scientific hypothesis, prepare and realise a scientific experiment. These activities' main aim are theoretical and practical mastering methods for chemical studies of biologically active compounds. The students' abilities after completion of the study will result from frame topics which are: design of novel biologically active compounds, total synthesis of biological active compounds, chemical modification of natural compounds with goal to increased their biological activities, structure determination of prepared compounds, analytical evaluation of reaction mixtures as well as isolated products, drugs and biologically active compounds, study of physicochemical properties of prepared compounds, study of interactions between biologically active compounds and lipids, proteins and DNA extracted from biological sources, evaluation of biological activities of biologically active compounds at different levels (in silico, in vitro, in vivo), evaluation of the toxicological effect of drugs and biologically active compounds on model organisms in relation to their impact on the human body and the environment. To achieve necessary research results during the study, it is required that students not only acquire theoretical knowledge, but also gain skills in the field of modern synthetic methods, preparative and analytical instrumental methods, used in pharmaceutical chemistry.
Graduates from the PhD. study programme Pharmaceutical Chemistry, doctoral university study, will master scientific work principles and methodology. They will be able to perform professional and scientific activities in pharmacy, chemistry, and pharmaceutical research. The academic knowledge and practical skills they acquired during the study will allow them to work as researchers in related medical, pharmaceutical, and natural science branches, such as e. g., inorganic chemistry, organic chemistry, analytical chemistry, biochemistry, physical chemistry, nuclear chemistry, and medical chemistry. Knowledge and skills will also be used in solving multidisciplinary problems with connection to pharmaceutical technology, pharmacology, etc. The graduates can work independently in science and bring their solutions to the branches mentioned above.
The requirement for completion of the study programme is the knowledge and further development of methods of research and development of new synthetic drugs including design, synthesis, analysis, and evaluation of bioactive compounds. A successful graduate of the doctoral studies must prove that he has not only required theoretical knowledge in the field, but also practical research skills in the field of pharmaceutical chemistry and is able to work independently. At the same time, he must be able to present results of his own research to the professional community at conferences and scientific events and publish articles in scientific journals.

Prospects of graduates
The doctoral study focuses on deeper specialisation and strengthening of theoretical and scientific knowledge in the professional preparation of an expert in pharmaceutical chemistry. Graduates from the study programme find employment at all universities where pharmaceutical chemistry, bioinorganic chemistry, bioorganic chemistry, biophysics, chemical and instrumental analysis of biologically active compounds are taught, either as university teachers or scientific and research workers. Thanks to familiarising with a large spectrum of knowledge and practical skills, the graduates find employment at workplaces of the healthcare system (State institute for drug control, and so on.) and in research laboratories of the Slovak Academy of Sciences. A graduate may also find an employment as researchers, developmental, and professional workers in the private sector's pharmaceutical industry which are associated in Asociácia inovatívneho farmaceutického priemyslu or in Asociácia pre generické a biosimilárne lieky GENAS.

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